Police said a Vauxhall Tigra left the B7078 Carlisle Road and hit a wall at about 2000 BST on Friday.
The driver died at the scene. The 19-year-old front seat passenger was in a critical condition.
Another man, 19, who was in the back seat, was airlifted to the Southern General in Glasgow. A female passenger, also 19, was in a stable condition.
Police said it appeared the driver had lost control of the car.
The front seat passenger was taken by ambulance to Wishaw General Hospital and then transferred to the Southern General Hospital in Glasgow.
The male back seat passenger, who was airlifted to hospital, was in a serious condition.
The female passenger was being treated at Wishaw General.
No other vehicle was involved in the crash.
Sgt Brian McGeogh, from Strathclyde Police, urged any motorists who were in the area at the time of the crash to come forward.
A full report will be sent to the procurator fiscal.
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